While both groups showed increased muscle mass, there were no significant hormonal differences between either repetition group for any outcomes. Researchers took blood samples and performed hormonal analyses. The study lasted 12 weeks, during which each volunteer performed a whole body resistance exercise training routine four days per week and received 30 grams of whey protein per day. The high repetition group performed exercised with low resistance but a larger number of repetitions until volitional failure, while the low repetition group performed exercises with a relatively heavy resistance with fewer repetitions until volitional failure.
In one study, 49 resistance-trained young men were randomly placed into either a high repetition or low repetition group. This means that DIM may actually make it harder to gain muscle mass. This means that it lowers the number of testosterone receptors. Furthermore, it also lowers the expression of androgen receptors in testicular and prostate tissue. However, DIM appears to block both testosterone and estrogen. Going with this reasoning men take DIM with the hopes of blocking estrogen or boosting testosterone. 2ĭo higher testosterone levels correlate with increased muscle growth? The anecdotal evidence says so as steroids are commonly used to increase muscle growth. This suggests that DIM may actually have estrogen and testosterone blocking affects at lower doses. DIM at 10mg/kg also lowered the number of androgen receptors expressed in testicular and prostate tissue. That dose did not affect sperm growth or testicular tissue. It also lowered estrogen levels from 8.00 pg/mL in controls to 4.56 pg/mL. In the study DIM at 10 mg/kg (a dose of 700 mg for the average 70 kg man) slightly lowered testosterone levels from 4.77 ng/mL in control subjects to 3.81 ng/mL. Researchers monitored spermatological parameters as well as serum testosterone and estradiol levels. The control group received corn oil, while the other three received varying amounts of DIM for a study period of 53 days. In one study, 38 male rats were split into four different groups. Does DIM boost testosterone production? Let’s find out. One of the reasons why many men choose to take DIM supplements is to boost testosterone production for athletic and bodybuilding purposes. Let’s take a look at the research to see if DIM can actually do these things.ĭIM may affect hormones in both men and women. DIM has been reported to boost testosterone, help with prostate cancer, and help acne. We conclude that BR-DIM is well tolerated at single doses of up to 200 mg, and that increasing the dose to 300 mg did not result in an increase in C(max).DIM, or diindolylmethane, is a compound that forms in the body from the breakdown of plant substances, most commonly cruciferous vegetables, including broccoli, cabbage, cauliflower, and Brussels sprouts.
The single 300-mg dose of BR-DIM resulted in a mean C(max) of 108 ng/mL and a mean AUC of 532 h ng/mL. The single 100-mg dose of BR-DIM resulted in a mean maximum plasma concentration (C(max)) of 32 ng/mL and a mean area under the curve (AUC) of 128 h ng/mL, and a single 200-mg dose produced a mean C(max) of 104 ng/mL and a mean AUC of 553 h ng/mL.
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Analysis of serial plasma samples showed that only one subject at the 50-mg dose had detectable concentrations of DIM. Only the latter effect was judged as probably related to the study agent. At the 300-mg dose, one of six subjects reported mild nausea and headache and one also reported vomiting. No BR-DIM-related adverse effects were reported at doses up to 200 mg.
The doses administered were 50, 100, 150, 200, and 300 mg, with the 300-mg dose repeated in an additional group. After randomization, one subject in each group received placebo whereas three received active BR-DIM. Groups of four subjects were enrolled for each dose level. We determined the safety, tolerability, and pharmacokinetics of single doses of BR-DIM in drug-free, non-smoking, healthy men and women. The study agent was nutritional-grade, absorption-enhanced BioResponse 3,3'-diindolylmethane (BR-DIM). We have completed a single ascending dose clinical study of the proposed chemopreventive agent 3,3'-diindolylmethane (DIM).
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